- 专利标题： PEPTIDE-BASED COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE
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申请号： US17642499申请日： 2020-09-11
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公开(公告)号： US20220332758A1公开(公告)日： 2022-10-20
- 发明人: Pawel A. OSMULSKI , Maria Gaczynska , Andrew Pickering , Przemyslaw Karpowicz , Elzbieta Jankowska
- 申请人： Board of Regents, The Universityof Texas System
- 申请人地址： US TX Austin
- 专利权人： Board of Regents, The Universityof Texas System
- 当前专利权人： Board of Regents, The Universityof Texas System
- 当前专利权人地址： US TX Austin
- 国际申请： PCT/US2020/050428 WO 20200911
- 主分类号： C07K7/02
- IPC分类号： C07K7/02 ; A61P25/28 ; C07K5/083
摘要：
Disclosed herein, are peptides capable of activating proteasome activity, and pharmaceutical compositions containing the peptides and methods treating Alzheimer's disease. Disclosed herein are compositions comprising: A) a peptide, wherein the peptide comprises the amino acid sequence GRKKR-RQ-AibG-RPS (SEQ ID NO: 4), or a fragment or variant thereof, B) a peptide, wherein the peptide comprises the amino acid sequence GRKKRRQ-AibG-QR-RKKRG (SEQ ID NO: 5), or a fragment or variant thereof, or C) a peptide, wherein the peptide comprises the amino acid sequence KKK/KKK-DABA-K KK (SEQ ID NO: 6) or a fragment or variant thereof.
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