Provided is a literature information service method using a single computer or a plurality of computers connected to each other via a network. The literature information service method includes: transmitting a first character string to a plurality of first servers connected respectively to a plurality of databases each including information of enzymes, and receiving a plurality of pieces of data obtained by searching the plurality of databases with the first character string; extracting a plurality of second character strings indicating information of enzymes from the plurality of pieces of data; generating a search expression using at least one of the plurality of extracted second character strings; and searching a literature database using the search expression to acquire search result data.