A cross button and a game controller with Dpad are provided. The cross button includes a button cap, a silicone pad, a circuit board and a controller. The circuit board is communicatively connected to the controller, and the silicone pad is located between the button cap and the circuit board. A first anti-mistouch pillar and four first trigger pillars are disposed on the silicone pad, and they are located on a side on the silicone pad close to the circuit board. The four first trigger pillars are evenly distributed on the silicone pad, and the first anti-mistouch pillar is located at a center of the four first trigger pillars. When all of the four first trigger pillars trigger signals, the controller controls a virtual button to trigger. A virtual button function of cross button is added without changing the original button, so the applicability of the cross button is enhanced.