- 专利标题： Benzoimidazole Derivatives As Anticancer Agents
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申请号： US17831592申请日： 2022-06-03
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公开(公告)号： US20220348587A1公开(公告)日： 2022-11-03
- 发明人: Toufic RENNO , Isabelle COSTE-INVERNIZZI , Stéphane GIRAUD , Serge LEBECQUE
- 申请人： CENTRE LEON BERARD , HOSPICES CIVILS DE LYON , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHESCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- 申请人地址： FR Lyon; FR Lyon; FR Villeurbanne; FR Paris; FR Paris
- 专利权人： CENTRE LEON BERARD,HOSPICES CIVILS DE LYON,UNIVERSITE CLAUDE BERNARD LYON 1,CENTRE NATIONAL DE LA RECHERCHESCIENTIFIQUE (CNRS),INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- 当前专利权人： CENTRE LEON BERARD,HOSPICES CIVILS DE LYON,UNIVERSITE CLAUDE BERNARD LYON 1,CENTRE NATIONAL DE LA RECHERCHESCIENTIFIQUE (CNRS),INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- 当前专利权人地址： FR Lyon; FR Lyon; FR Villeurbanne; FR Paris; FR Paris
- 优先权： EP16306203.7 20160920
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K45/06 ; C07D235/18 ; C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D403/04 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; C07D417/12
摘要：
The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing the compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.
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