Invention Application
- Patent Title: CONVERGENT LIQUID PHASE SYNTHESES OF OLIGONUCLEOTIDES
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Application No.: US17608802Application Date: 2020-05-08
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Publication No.: US20220348602A1Publication Date: 2022-11-03
- Inventor: Xianglin Shi , William F. Kiesman , Firoz Antia , Yannick Fillon , Xuan Zhou , Wuming Yan , Hong Jiang , Hien Nguyen , Robert S. Gronke , Taisuke Ichimaru , Takuya Hamagaki , Daisuke Takahashi
- Applicant: BIOGEN MA Inc. , AJINOMOTO CO., Inc.
- Applicant Address: US MA Cambridge; JP Tokyo
- Assignee: BIOGEN MA Inc.,AJINOMOTO CO., Inc.
- Current Assignee: BIOGEN MA Inc.,AJINOMOTO CO., Inc.
- Current Assignee Address: US MA Cambridge; JP Tokyo
- International Application: PCT/US2020/032070 WO 20200508
- Main IPC: C07H1/02
- IPC: C07H1/02 ; C07H21/02
Abstract:
The present disclosure describes a convergent liquid phase process for manufacturing oligonucleotides by coupling two or more oligonucleotide fragments, each of which have two or more nucleotides. Also provided by the present disclosure are reaction steps involved the convergent liquid phase process.
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