A neckband headphone, a method, a system and a device for starting up a neckband headphone, as well as a computer readable storage medium are provided. The neckband headphone according to the present disclosure includes a neckband, a first earbud connected to an end of the neckband, a second earbud connected to another end of the neckband, a detector, and a processor connected to the detector. The detector is configured to acquire state information of the neckband headphone. The processor is configured to: determine whether the neckband headphone is worn based on the state information; control the neckband headphone to wake up when determining that the neckband headphone is worn, and control the neckband headphone to be in a low-power mode when determining that the neckband headphone is not worn.