- 专利标题： 5-(Thiophen-2-YL)-1 H-Tetrazole Derivative as BCKDK Inhibitors Useful for Treating Various Diseases
-
申请号： US17619912申请日： 2020-06-24
-
公开(公告)号： US20220363673A1公开(公告)日： 2022-11-17
- 发明人: Samit Kumar Bhattacharya , Christopher Ryan Butler , Kevin James Filipski , Bethany Lyn Kormos , Luis Angel Martinez-Alsina , Russell Alan Miller , Kiyoyuki Omoto , Brian Raymer , Matthew Richard Reese , Rachel Jane Roth Flach , Yuan Zhang
- 申请人： Pfizer Inc.
- 申请人地址： US NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： US NY New York
- 国际申请： PCT/IB2020/055974 WO 20200624
- 主分类号： C07D409/04
- IPC分类号： C07D409/04 ; A61K45/06 ; A61K31/41 ; A61P3/10 ; A61P9/04
摘要：
Described herein are compounds of Formula I, wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure.