A device and system for managing medication delivery devices includes a case with a housing having an opening for receiving a medication delivery device. A cover is configured and arranged to cover the opening. A medication delivery device such as: an auto injector is disposed in the housing. A sensor to detect the position of the cover may be provided. An electronic control system is operatively associated with the housing and disposed in wireless communication with a gateway device. The electronic control system is configured and arranged to provide a signal to the gateway device when the case is within, proximity of the gateway device. The electronic control system is also configured and arranged to transmit corresponding signals to the gateway device based on the position of the cover, the presence of the medication delivery device in the case, and/or the activation of the delivery device.