The present disclosure provides a display substrate and a display panel. The display substrate has a display area and a peripheral area surrounding the display area; the display area includes first and second display sub-areas; the display substrate includes a base substrate, and a driving circuit layer and multiple light-emitting devices on the base substrate; the driving circuit layer includes multiple pixel driving circuits, a gate driving circuit, and a light emission control circuit; a first electrode of each light-emitting device is electrically coupled to one pixel driving circuit; the multiple pixel driving circuits include first pixel driving circuits for providing driving signals for light-emitting devices in the first display sub-area, and second pixel driving circuits for providing driving signals for light-emitting devices in the second display sub-area; and the light emission control circuit includes first and second light emission control sub-circuits disconnected from each other.