The present disclosure provides decontamination system that includes a decontamination chamber for sealably holding one or more items for decontamination. The system also includes a decontamination unit comprising: a controllable air heater and humidity control unit to controllably heat an ambient air source and to control a temperature and humidity of air within a decontamination chamber; a controllable vaporizer unit to controllably vaporize one or more decontamination agents by combining the controllably heated ambient air with the one or more decontamination agents; and controller circuitry to control a controllable air heater and humidity control unit to heat the ambient air to a selected level, and to maintain a selected heat and humidity within the decontamination chamber, and to control the controllable vaporizer unit to provide a selected flow rate of the one or more decontamination agents into the decontamination chamber.