An electronic paper display screen and a manufacturing method therefor, and a display device. The electronic paper display screen includes a first electronic paper screen and a second liquid crystal display layer which are stacked; the first electronic paper screen is an electrophoretic electronic paper screen, the second liquid crystal display layer is a cholesteric liquid crystal display screen, and the second liquid crystal display layer includes a first substrate, a second substrate and a control drive circuit; the first substrate is provided with multiple first electrodes arranged in a first direction, and the second substrate is provided with multiple second electrodes arranged in a second direction; and at least one of the first substrate and the second substrate is further provided with multiple metal wires, the metal wires are respectively connected to the control drive circuit and the electrodes of the substrate to which the metal wires belong.