Embodiments of the present disclosure relate to computer storage, methods, and systems for the optimization of accessible color themes. Systems and methods are disclosed that leverage the use of confusion lines to identify and highlight relationships between colors that may be inaccessible (e.g., indistinguishable) for a person with a vision impairment, such as a color vision deficiency. In some embodiments, a graphical user interface is provided that, based on a selection of colors in a color wheel, visually indicates curves of confusion for each color in the selection of colors. Each curve of confusion visually indicates a confusion of colors for a type of vision impairment, such as a CVD.