Invention Application
- Patent Title: ENGINEERING CHARGE PAIR MUTATIONS FOR PAIRING OF HETERO-IgG MOLECULES
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Application No.: US17775063Application Date: 2020-11-06
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Publication No.: US20220389119A1Publication Date: 2022-12-08
- Inventor: Bram ESTES , Fernando GARCES , Zhulun WANG , Mark DARIS
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- International Application: PCT/US2020/059378 WO 20201106
- Main IPC: C07K16/46
- IPC: C07K16/46
Abstract:
The present invention relates to heterodimers comprising antibody CH3 domains and mutations useful for the facilitation of the formation of heterodimers. Methods of optimizing purification of the heterodimers at certain pHs in also disclosed.
Information query
