The present disclosure provides a protective film and a method for manufacturing same, a touch panel, and a display device, which belongs to the field of display devices. The protective film includes a transparent substrate layer and a transparent hardened layer covering a surface of the transparent substrate layer. The transparent hardened layer includes a first region covering a middle portion of the transparent substrate layer and a second region covering an edge of the transparent substrate layer, wherein hardness of the first region is greater than hardness of the second region. The transparent hardened layer includes the first region and the second region. As a result, the first region disposed on the middle portion of the transparent substrate layer may provide better protection, and the second region disposed at the edge of the transparent substrate layer may avoid burrs or dents formed during cutting, such that air bubbles are not easily generated after the transparent hardened layer is attached to the substrate, and warping and deformation are not easily caused by impacts of ambient temperature and humidity.