A three-proof earbuds box protective case includes a bottom housing and a top cover mounted at the upper end of the bottom housing and can be opened or closed. One side of the bottom housing and one side of the top cover are hinged. A waterproof and dustproof ring is provided between the bottom housing and the top cover. The lower end of the bottom housing has a first shockproof flexible rubber having a first shockproof part fixed to the lower end surface of the bottom housing, and a second shockproof part fixed to the inner wall of the bottom housing. The upper end of the top cover has a second shockproof flexible rubber having a third shockproof part fixed to the upper end surface of the top cover, and a fourth shockproof part fixed to the inner wall of the top cover.