- 专利标题： ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF
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申请号： US17741206申请日： 2022-05-10
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公开(公告)号： US20220411404A1公开(公告)日： 2022-12-29
- 发明人: David A. Scott , David Heppner , Thomas Gero , Courtney A. Cullis , Ciric To , Shih-Chung Huang , Yongbo Hu , Steve Stroud , Tyler Beyett , Michael Eck , Nathanael S. Gray
- 申请人： Dana-Farber Cancer Institute, Inc.
- 申请人地址： US MA Boston
- 专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人地址： US MA Boston
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D471/04 ; C07D473/00 ; C07D495/14
摘要：
The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.
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