- 专利标题： DEVELOPMENT OF A NOVEL LIVE ATTENUATED AFRICAN SWINE FEVER VACCINE BASED IN THE DELETION OF GENE A137R
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申请号： US17363875申请日： 2021-06-30
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公开(公告)号： US20230000967A1公开(公告)日： 2023-01-05
- 发明人: DOUGLAS P. GLADUE , MANUEL V. BORCA
- 申请人： The United States of America, as represented by the Secretary of Agriculture
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as represented by the Secretary of Agriculture
- 当前专利权人： The United States of America, as represented by the Secretary of Agriculture
- 当前专利权人地址： US DC Washington
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61P31/20 ; C12N7/00
摘要：
Provided herein are details on the construction of a recombinant African Swine Fever Virus (ASFV) live attenuated vaccine for prevention of ASF caused by various strains of ASFV, such as the highly virulent Georgia 2007 isolate (“ASFV-G”). An exemplary vaccine comprises the ASFV-GΔA137R modified virus, a recombinant ASFV-G modified by deleting a portion of the A137R ORF rendering the A137R gene nonfunctional.
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