- 专利标题： A CONJUGATION LINKER CONTAINING 2,3-DIAMINOSUCCINYL GROUP
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申请号： US17284091申请日： 2018-10-12
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公开(公告)号： US20230010108A1公开(公告)日： 2023-01-12
- 发明人: Robert Yongxin ZHAO , Qingliang YANG , Yuanyuan HUANG , Linyao ZHAO , Hangbo YE , Xiaotao ZHUO , Chengyu YANG , Jun LEI , Yifang XU , Huihui GUO , Wenjun LI , Shun GAI , Lu BAI , Zhixiang GUO , Junxiang JIA , Jun ZHENG , Xiaomai ZHOU , Hongsheng XIE , Qianqian TONG , Mingjun CHAO , Yanhong TONG , Zhicang YE , Chen LIN , Yanlei YANG , Binbin CHEN
- 申请人： Hangzhou DAC Biotech Co., Ltd.
- 申请人地址： CN Hangzhou, Zhejiang
- 专利权人： Hangzhou DAC Biotech Co., Ltd.
- 当前专利权人： Hangzhou DAC Biotech Co., Ltd.
- 当前专利权人地址： CN Hangzhou, Zhejiang
- 国际申请： PCT/CN2018/110155 WO 20181012
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D417/12 ; C07D413/14 ; C07D417/14 ; C07D403/14 ; C07D498/22 ; C07D498/12 ; A61K47/54 ; A61K45/06 ; A61K47/68
摘要：
The present invention relates to a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (a dual-linker) containing a 2,3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.