- 专利标题： CRYSTALLINE FORM OF ACETYLCHOLINESTERASE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
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申请号： US17780449申请日： 2020-11-24
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公开(公告)号： US20230010368A1公开(公告)日： 2023-01-12
- 发明人: Hong LIU , Yu ZHOU , Haiyan ZHANG , Yan FU , Jian LI , Hualiang JIANG , Xican TANG , Kaixian CHEN
- 申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , JIANGSU KANION PHARMACEUTICAL CO., LTD.
- 申请人地址： CN Shanghai; CN Lianyungang
- 专利权人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES,JIANGSU KANION PHARMACEUTICAL CO., LTD.
- 当前专利权人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES,JIANGSU KANION PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： CN Shanghai; CN Lianyungang
- 优先权： CN201911176960.2 20191126
- 国际申请： PCT/CN2020/131119 WO 20201124
- 主分类号： C07D211/38
- IPC分类号： C07D211/38
摘要：
The present invention provides a crystalline form of an acetylcholinesterase inhibitor, a preparation method therefor and application thereof. Specifically, the crystalline form is crystalline form A, crystalline form B and crystalline form C of 2-((1-(2-fluorobenzyl)-4-fluoropiperidin-4-yl) methylene)-5, 6-dimethoxy-2, 3-dihydro-1-indanone. The crystalline form of the present invention does not contain water and solvent, has high stability and low hygroscopicity, is easy to process, and is very suitable for preparing drugs for preventing and/or treating neurodegenerative diseases.