A technique is configured to provide various data protection schemes, such as replication and erasure coding, for data blocks of volumes served by storage nodes of a cluster configured to perform deduplication of the data blocks. Additionally, the technique is configured to ensure that each deduplicated data block complies with data redundancy guarantees of the data protection schemes, while improving storage space of the storage nodes. In order to satisfy the data integrity guarantees while improving available storage space, the storage nodes perform periodic garbage collection for data blocks to optimize storage in accordance with currently applicable data protection schemes.