Invention Publication
- Patent Title: MATERIALS AND METHODS RELATING TO IMMUNOGENIC EPITOPES FROM HUMAN PAPILLOMAVIRUS
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Application No.: US18046817Application Date: 2022-10-14
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Publication No.: US20230143555A1Publication Date: 2023-05-11
- Inventor: Sri KRISHNA , Marshall POSNER , Andrew SIKORA , Karen ANDERSON
- Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , BAYLOR COLLEGE OF MEDICINE
- Applicant Address: US AZ Scottsdale
- Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY,ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI,BAYLOR COLLEGE OF MEDICINE
- Current Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY,ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI,BAYLOR COLLEGE OF MEDICINE
- Current Assignee Address: US AZ Scottsdale
- The original application number of the division: US16762085 2020.05.06
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61P31/20 ; A61P35/00
Abstract:
Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.
Public/Granted literature
- US1260709A Eye for handles and the like. Public/Granted day:1918-03-26
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