发明公开
- 专利标题: COMPOSITIONS AND METHODS FOR REDUCING GRAFT REJECTION IN ALLOGENEIC CELL THERAPY
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申请号: US17916370申请日: 2021-04-01
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公开(公告)号: US20230149461A1公开(公告)日: 2023-05-18
- 发明人: Zhongyuan TU , Jie LI , Yafeng ZHANG , Shu WU
- 申请人: Nanjing Legend Biotech Co., Ltd.
- 申请人地址: CN Nanjing, Jiangsu
- 专利权人: Nanjing Legend Biotech Co., Ltd.
- 当前专利权人: Nanjing Legend Biotech Co., Ltd.
- 当前专利权人地址: CN Nanjing, Jiangsu
- 优先权: CN TCN2020082759 2020.04.01
- 国际申请: PCT/CN2021/084956 2021.04.01
- 进入国家日期: 2022-09-30
- 主分类号: A61K35/17
- IPC分类号: A61K35/17 ; C12N5/0783 ; A61K38/17 ; A61K35/15 ; A61P37/06 ; A61P35/00
摘要:
Provided are modified therapeutic cells that overexpress an immune checkpoint ligand such as PD-L1, CD155, CD112, FGL1, galectin-9, CD47, B7H3 and B7H4, while expressing one or more Major Histocompatibility Complex (MHC) molecules. Also provided are methods of treatment using the modified therapeutic cells.
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