A noise suppression method and system for Inverse Synthetic Aperture Radar micro-cluster objects using a generative adversarial network (GAN) are provided. The method includes: constructing the GAN, including a generator and a discriminator; obtaining and inputting noisy simulation data into the generator to obtain a first output, comparing the first output with noiseless simulation data to obtain a first generator loss, inputting the first output and the distribution function into the discriminator for denoising discrimination to obtain a first discriminant result, and determining a second generator loss according to the first generator loss and the first discriminate result; and obtaining measured data and inputting the measured data into the generator to obtain a second output, inputting the second output to the discriminator to obtain a second discriminant result, and determining a generator loss according to the second generator and the second discriminate result.