A system, method and computer program product for synthesizing sensor data in a wearable device. Sensor readings are obtained from a plurality of sensors, the plurality of sensors arranged in a first predetermined pattern, where the first predetermined pattern maps each of the plurality of sensors to respective locations on the wearable device. Based on the plurality of sensor readings and a plurality of estimation weights, a plurality of synthesized sensor readings are estimated for a corresponding plurality of synthesized sensors. The plurality of synthesized sensors are arranged in a second predetermined pattern, wherein the second predetermined pattern maps each of the plurality of synthesized sensors to respective locations on the wearable device. The plurality of sensor readings and the plurality of synthesized sensor readings can be output to provide a comprehensive set of sensor readings. The estimation weights can be optimized in a preprocessing phase.