A barcode reader configured to capture interleaved frame types optimized for vision capture and barcode capture are disclosed herein. An example barcode reader is configured to operate in a pre-determined repetitive pattern of capturing a first frame and capturing a second frame over a reading cycle having a fixed duration after a triggering event, wherein the first frame is captured over a first exposure period having a first duration, and the second frame is captured over a second exposure period having a second duration, and wherein the first frame is associated with a first brightness parameter, and the second frame is associated with a second brightness parameter.