- 专利标题： Methods for Diagnosing and/or Predicting the Risk of Having an Acute Rejection (AR) in a Kidney Transplant Recipient
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申请号： US17996848申请日： 2021-04-21
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公开(公告)号： US20230162860A1公开(公告)日： 2023-05-25
- 发明人: Dany ANGLICHEAU , Claire TINEL
- 申请人： NSERM (Institut National de la Santé et de la Recherche Médicale) , Centre National de la Recherche Scientifique (CNRS) , Université Paris Cité , Assistance Publique-Hôpitaux de Paris (APHP)
- 申请人地址： FR Paris
- 专利权人： NSERM (Institut National de la Santé et de la Recherche Médicale),Centre National de la Recherche Scientifique (CNRS),Université Paris Cité,Assistance Publique-Hôpitaux de Paris (APHP)
- 当前专利权人： NSERM (Institut National de la Santé et de la Recherche Médicale),Centre National de la Recherche Scientifique (CNRS),Université Paris Cité,Assistance Publique-Hôpitaux de Paris (APHP)
- 当前专利权人地址： FR Paris
- 优先权： EP 305388.9 2020.04.22
- 国际申请： PCT/EP2021/060415 2021.04.21
- 进入国家日期： 2022-10-21
- 主分类号： G16H50/20
- IPC分类号： G16H50/20 ; G01N33/68 ; C12Q1/70 ; G16H50/30
摘要：
By using a fully phenotyped cohort of kidney transplant recipients (KTRs), inventors have clearly established the clinical conditions that should be considered when using urinary chemokine levels to noninvasively identify patients at risk of acute rejection (AR). They have developed and validated (in two external validation cohorts) a multiparametric model that predicts individual risk of AR with high accuracy. Accordingly, the invention relates to a method for calculating a probability (p) to have a risk of an acute rejection (AR) in a kidney transplant recipient by using the following equation: (I)
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