A method and an apparatus of transmitting and receiving control information in a wireless communication system is disclosed. A method of transmitting control information in a wireless communication system according to an embodiment of the present disclosure may include receiving, from a base station, first configuration information for configuring HARQ (Hybrid Automatic Repeat and request)-ACK (acknowledgement) bundling for one or more serving cells among a plurality of serving cells configured for the terminal; receiving, from the base station, downlink control information (DCI) for scheduling one or more physical downlink shared channels (PDSCH) on each of the plurality of serving cells; receiving, from the base station, a plurality of PDSCHs on the plurality of serving cells; and transmitting, to the base station, control information including a HARQ-ACK codebook generated based on HARQ-ACK information for the plurality of PDSCHs.