A sterilization bag includes: a bag body, provided with an accommodation space and opening, the opening in communication with the accommodation space, and the accommodation space provided with at least one optical surface; and a ultraviolet light source, configured in the accommodation space, allowing the ultraviolet light source to irradiate the at least one optical surface. Whereby, the ultraviolet light source can disinfect and sterilize the accommodation space of the bag body to eliminate viruses and bacteria in the air or on an item, thereby having an epidemic prevention effect.