An electrocardiogram (ECG) acquisition system comprises a processor configured to process an ECG signal from a patient, a plurality of ECG electrodes configured to be coupled to the patient to obtain the ECG signal from the patient, and an analog-to-digital (A/D) converter configured to acquire the ECG signal from the plurality of ECG electrodes, and to provide the ECG signal to the processor as ECG data representative of the ECG signal. The A/D converter is configured to acquire the ECG signal at a first resolution and the processor is configured to process the ECG data at a second resolution, and the first resolution is higher than the second resolution.