Invention Publication
- Patent Title: FORMULATION CONTAINING HMGB1 PARTIAL PEPTIDE
-
Application No.: US17919872Application Date: 2021-04-19
-
Publication No.: US20230173027A1Publication Date: 2023-06-08
- Inventor: Nao MATSUOKA , Shuichi HATANO , Yuya KUGA , Maki OKABE , Takehiko YAMAZAKI , Koichi YOKOTA
- Applicant: Shionogi & Co., Ltd. , StemRim Inc.
- Applicant Address: JP Osaka-shi, Osaka
- Assignee: Shionogi & Co., Ltd.,StemRim Inc.
- Current Assignee: Shionogi & Co., Ltd.,StemRim Inc.
- Current Assignee Address: JP Osaka-shi, Osaka; JP Ibasaki-shi, Osaka
- Priority: JP 20074929 2020.04.20
- International Application: PCT/JP2021/015792 2021.04.19
- Date entered country: 2022-10-19
- Main IPC: A61K38/19
- IPC: A61K38/19 ; A61K47/12 ; A61K47/26 ; A61K47/02 ; A61K9/19

Abstract:
A pharmaceutical composition containing the substance according to any one of the following (a) to (c), an organic acid, a metal salt of an organic acid, and a sugar and/or a sugar alcohol, wherein when the pharmaceutical composition is dissolved in distilled water for injection, a pH of the pharmaceutical composition is 3.0 to 4.5, the substance according to any one of the following (a) to (c) can be stabilized;
(a) an HMGB1 fragment peptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or an acid addition salt thereof;
(b) a peptide comprising an amino acid sequence having substitution, deletion, insertion or addition of one or more amino acids in the amino acid sequence set forth in SEQ ID NO: 1, and having an activity of stimulating migration of a cell, or an acid addition salt thereof; and
(c) a peptide comprising an amino acid sequence having about 80% or more of sequence identity to the amino acid sequence set forth in SEQ ID NO: 1, and having an activity of stimulating migration of a cell, or an acid addition salt thereof.
(a) an HMGB1 fragment peptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or an acid addition salt thereof;
(b) a peptide comprising an amino acid sequence having substitution, deletion, insertion or addition of one or more amino acids in the amino acid sequence set forth in SEQ ID NO: 1, and having an activity of stimulating migration of a cell, or an acid addition salt thereof; and
(c) a peptide comprising an amino acid sequence having about 80% or more of sequence identity to the amino acid sequence set forth in SEQ ID NO: 1, and having an activity of stimulating migration of a cell, or an acid addition salt thereof.
Information query
IPC分类: