A fluidic system for fraction collection comprises a switching valve having a plurality of ports for connecting first and second ports in different configurations. An inlet line is directly connected to the first port, and a collection device is directly connected to the second port. In a collection configuration, the first port and the second port are connected. The ports further comprise third and fourth ports, and the fluidic system further comprises a buffer section directly connected to the third and fourth ports. The fluidic system further comprises a first collection reservoir and is configured to position the collection device to expel a fluid into the first collection reservoir. In a buffer configuration, fluid flows through the inlet line, the first port, the third port, the buffer section, the fourth port, the second port, and the collection device.