Invention Publication
- Patent Title: NOVEL COMPOUNDS FOR DIAGNOSIS
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Application No.: US17923771Application Date: 2021-05-07
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Publication No.: US20230174536A1Publication Date: 2023-06-08
- Inventor: Jerome MOLETTE
- Applicant: AC IMMUNE SA
- Applicant Address: CH Lausanne
- Assignee: AC IMMUNE SA
- Current Assignee: AC IMMUNE SA
- Current Assignee Address: CH Lausanne
- Priority: EP 173587.5 2020.05.07 EP 187551.5 2020.07.23
- International Application: PCT/EP2021/062215 2021.05.07
- Date entered country: 2022-11-07
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07B59/00 ; A61K51/04

Abstract:
The present invention relates to novel compounds of formula (I), or a detectably labelled compound, stereoisomer, racemic mixture, pharmaceutically acceptable salt, hydrate, or solvate thereof, that can be employed in the imaging of alpha-synuclein aggregates and determining an amount thereof. Furthermore, the compounds can be used for diagnosing a disease, disorder or abnormality associated with an alpha-synuclein aggregates, including, but not limited to, Lewy bodies and/or Lewy neurites (such as Parkinson's disease), determining a predisposition to such a disease, disorder or abnormality, prognosing such a disease, disorder or abnormality, monitoring the evolution of the disease in a patient suffering from such a disease, disorder or abnormality, monitoring the progression of such a disease, disorder or abnormality and predicting responsiveness of a patient suffering from such a disease, disorder or abnormality to a treatment thereof.
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