A display substrate (100) and a design method therefor, and a display apparatus. The display substrate (100) includes: pixel circuits which are arranged in an array, where the pixel circuits are divided into at least two areas; and data switching circuits (10), which are correspondingly connected to the pixel circuits in the areas by means of data signal lines, wherein a channel width-to-length ratio (W/L) of a switch device in each data switching circuit (10) is positively correlated with a design data load of an area corresponding to the data switching circuit (10). The width-to-length ratios (W/L) of different switch devices can be matched according to different design data loads of different areas.