- 专利标题: PARTICLE SUITABLE FOR THE MANUFACTURE OF AN IMPLANTABLE SOFT TISSUE ENGINEERING MATERIAL
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申请号: US18058909申请日: 2022-11-28
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公开(公告)号: US20230181794A1公开(公告)日: 2023-06-15
- 发明人: Amelie Beduer , Thomas Braschler , Philippe Renaud
- 申请人: Ecole Polytechnique Federale de Lausanne
- 申请人地址: CH Lausanne
- 专利权人: Ecole Polytechnique Federale de Lausanne
- 当前专利权人: Ecole Polytechnique Federale de Lausanne
- 当前专利权人地址: CH Lausanne
- 优先权: WO TCH201700090 2017.10.05
- 主分类号: A61L27/20
- IPC分类号: A61L27/20 ; A61F2/00 ; A61F2/12 ; A61L27/16 ; A61L27/18 ; A61L27/24 ; A61L27/52 ; A61L27/54 ; A61K9/14 ; A61L24/00 ; A61L27/36
摘要:
The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where:
(i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa;
(ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE;
(iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T;
(iv) the three-dimensionally warped and branched sheet (2) has a volume VS;
(v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and
(vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3);
(vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and
(viii) where the conduits (5) have (a) a mean diameter DC; and (b) an anisotropicity index of 1.01 to 5.00.
(i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa;
(ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE;
(iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T;
(iv) the three-dimensionally warped and branched sheet (2) has a volume VS;
(v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and
(vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3);
(vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and
(viii) where the conduits (5) have (a) a mean diameter DC; and (b) an anisotropicity index of 1.01 to 5.00.
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