Invention Publication
- Patent Title: COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5
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Application No.: US17998901Application Date: 2021-05-21
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Publication No.: US20230183237A1Publication Date: 2023-06-15
- Inventor: Craig W. Lindsley , Carrie K. Jones , P. Jeffrey Conn , Changho Han , Andrew S. Felts , Douglas L. Orsi , Julie L. Engers , Jinming Li , Rory A. Capstick , David L. Whomble , Kayla J. Temple
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- International Application: PCT/US2021/033574 2021.05.21
- Date entered country: 2022-11-15
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D417/14 ; C07D405/14 ; C07D513/04 ; C07D495/04 ; C07D487/04 ; C07D491/048 ; C07D519/00 ; C07D401/14 ; C07D413/14 ; C07D498/04 ; C07D401/12
Abstract:
Arylsulfonamides of 4-heteroaryl-piperidines, and their derivatives, are competitive and non-competitive inhibitors of the muscarinic acetylcholine receptor M5 (mAChR M5) and have utility in the treatment of psychiatric disorders such as substance-related misuse, substance-related disorder relapse, anxiety, depression, and psychosis.
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