发明公开
- 专利标题： MODULATOR ASSAY
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申请号： US17823356申请日： 2022-08-30
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公开(公告)号： US20230194541A1公开(公告)日： 2023-06-22
- 发明人: James Philip O'CONNELL , John Robert PORTER , Alastair LAWSON , Boris KROEPLIEN , Stephen Edward RAPECKI , Timothy John NORMAN , Graham John WARRELLOW
- 申请人： UCB BIOPHARMA SRL
- 申请人地址： BE Brussels
- 专利权人： UCB BIOPHARMA SRL
- 当前专利权人： UCB BIOPHARMA SRL
- 当前专利权人地址： BE Brussels
- 优先权： GB 10758.4 2015.06.18
- 分案原申请号： US16883859 2020.05.26
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; C07D401/14 ; C07K14/525 ; C07D471/00 ; C07K14/705 ; C07K16/24 ; C07D213/72 ; C07D235/04 ; C07D239/26 ; C07D471/04 ; A61K47/64 ; A61P37/00 ; A61P35/00
摘要：
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. Anew assay for identifying compounds with this mechanism of action is also disclosed.
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