- 专利标题: PHARMACEUTICAL COMPOSITION FOR TREATING FATTY LIVER DISEASE
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申请号: US17926273申请日: 2021-05-20
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公开(公告)号: US20230210822A1公开(公告)日: 2023-07-06
- 发明人: Hideo YUKIOKA , Atsuyuki SHIMAZAKI , Tadateru HAMADA , Naoki OHYABU
- 申请人: Shionogi & Co., Ltd.
- 申请人地址: JP Osaka
- 专利权人: Shionogi & Co., Ltd.
- 当前专利权人: Shionogi & Co., Ltd.
- 当前专利权人地址: JP Osaka
- 优先权: JP 20089196 2020.05.21 JP 20134338 2020.08.07
- 国际申请: PCT/JP2021/019088 2021.05.20
- 进入国家日期: 2022-11-18
- 主分类号: A61K31/4184
- IPC分类号: A61K31/4184 ; A61P1/16
摘要:
Provided is a pharmaceutical composition for treating and/or preventing fatty liver disease, particularly nonalcoholic fatty liver disease, the pharmaceutical composition having an excellent ACC2-selective inhibitory action and having no side effects such as an increase in plasma triglyceride or a decrease in platelet concentration.
A pharmaceutical composition for treating and/or preventing fatty liver disease, the pharmaceutical composition comprising a compound represented by Formula (I):
wherein
R1 is haloalkyl or non-aromatic carbocyclyl,
R2 is a hydrogen atom or halogen,
R3 is halogen,
ring A is a group represented by the formula:
-L1- is —O—(CH2)—, —(CH2)2—, or the like,
R4 is alkyl or haloalkyl, and
R5 is alkylcarbonyl or carbamoyl,
or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition for treating and/or preventing fatty liver disease, the pharmaceutical composition comprising a compound represented by Formula (I):
wherein
R1 is haloalkyl or non-aromatic carbocyclyl,
R2 is a hydrogen atom or halogen,
R3 is halogen,
ring A is a group represented by the formula:
-L1- is —O—(CH2)—, —(CH2)2—, or the like,
R4 is alkyl or haloalkyl, and
R5 is alkylcarbonyl or carbamoyl,
or a pharmaceutically acceptable salt thereof.
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