- 专利标题： ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF
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申请号： US18000722申请日： 2021-06-09
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公开(公告)号： US20230212171A1公开(公告)日： 2023-07-06
- 发明人: David A. Scott , Thomas Gero , Tyler Beyett , David Heppner , Krista E. Gipson , Shih-Chung Huang , Steve Stroud
- 申请人： David A. SCOTT , Thomas GERO , Tyler BEYETT , David HEPPNER , Krista E. GIPSON , Shih-Chung HUANG , Steve STROUD , Dana-Farber Cancer Institute, Inc.
- 申请人地址： US MA Newton
- 专利权人： David A. SCOTT,Thomas GERO,Tyler BEYETT,David HEPPNER,Krista E. GIPSON,Shih-Chung HUANG,Steve STROUD,Dana-Farber Cancer Institute, Inc.
- 当前专利权人： David A. SCOTT,Thomas GERO,Tyler BEYETT,David HEPPNER,Krista E. GIPSON,Shih-Chung HUANG,Steve STROUD,Dana-Farber Cancer Institute, Inc.
- 当前专利权人地址： US MA Newton
- 国际申请： PCT/US2021/036657 2021.06.09
- 进入国家日期： 2022-12-05
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D495/04 ; C07D513/04 ; C07D401/14 ; A61K45/06
摘要：
The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.
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