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US20230227554A1 CHIMERIC ANTIGEN RECEPTOR, MACROPHAGE EXPRESSING SAME, METHOD FOR ADJUSTING MACROPHAGE POLARIZATION, AND USE THEREOF 审中-公开

  • 专利标题： CHIMERIC ANTIGEN RECEPTOR, MACROPHAGE EXPRESSING SAME, METHOD FOR ADJUSTING MACROPHAGE POLARIZATION, AND USE THEREOF
  • 申请号： US17998092
    申请日： 2020-10-22
  • 公开(公告)号： US20230227554A1
    公开(公告)日： 2023-07-20
  • 发明人: Jin ZHANG , Lin TIAN , Anhua LEI
  • 申请人： ZHEJIANG UNIVERSITY
  • 申请人地址： CN Hangzhou
  • 专利权人： ZHEJIANG UNIVERSITY
  • 当前专利权人： ZHEJIANG UNIVERSITY
  • 当前专利权人地址： CN Hangzhou
  • 优先权： CN 2010383935.8 2020.05.08
  • 国际申请： PCT/CN2020/122901 2020.10.22
  • 进入国家日期： 2022-11-07
  • 主分类号： C07K16/28
  • IPC分类号： C07K16/28 ;  C07K14/57 ;  C12N5/0786
CHIMERIC ANTIGEN RECEPTOR, MACROPHAGE EXPRESSING SAME, METHOD FOR ADJUSTING MACROPHAGE POLARIZATION, AND USE THEREOF
摘要：
Provided are a chimeric antigen receptor, a macrophage expressing same, a method for adjusting macrophage polarization, and the use thereof. The intracellular domain of the chimeric antigen receptor contains an IFN-γ receptor, and the macrophage expressing the chimeric antigen receptor can maintain an M1 type status for a relatively long time, thereby enhancing the activity of the macrophage M1 type after tumor cell antigens are combined with the chimeric antigen receptor.
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