Invention Publication
- Patent Title: METHODS AND COMPOSITIONS FOR TREATING EPILEPSY
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Application No.: US18154241Application Date: 2023-01-13
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Publication No.: US20230227829A1Publication Date: 2023-07-20
- Inventor: Valérie CREPEL , Christophe MULLE , Céline BOILEAU , Séverine DEFORGES , Olivier DANOS , Andrew MERCER , Richard PORTER , April R. TEPE
- Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ D'AIX-MARSEILLE , UNIVERSITÉ DE BORDEAUX , REGENXBIO INC. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CORLIEVE THERAPEUTICS
- Applicant Address: FR MD Paris
- Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITÉ D'AIX-MARSEILLE,UNIVERSITÉ DE BORDEAUX,REGENXBIO INC.,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,CORLIEVE THERAPEUTICS
- Current Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITÉ D'AIX-MARSEILLE,UNIVERSITÉ DE BORDEAUX,REGENXBIO INC.,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,CORLIEVE THERAPEUTICS
- Current Assignee Address: FR MD Paris
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12N15/86 ; A61P25/08
Abstract:
The present disclosure provides methods and compositions relating to gene therapy for treating epilepsy, such as a temporal lobe epilepsy, in a subject in need thereof by targeting Grik2 mRNA. In particular, the present disclosure provides inhibitory RNA constructs capable of inhibiting expression of GluK2 protein and inhibiting epileptiform discharges in hyperexcitable neuronal circuit.
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