Provided are a silicone stent (100), an implantation system, and a manufacturing method. The silicone stent (100) includes a stent body (110). The stent body (110) includes a mesh frame (112) and a silicone body (111) molded on the mesh frame (112). A circumferentially sealed space (116) is defined within the silicone body (111). A distal end and a proximal end of the silicone body (111) respectively have a distal-end opening (115) and a proximal-end opening (114) that communicate with the space (116). The mesh frame (112) circumferentially covers the silicone body (111), and runs in an axial direction of the silicone body (111). The mesh frame (112) extends from the proximal end of the silicone body (111) to the distal end of the silicone body (111).