发明公开
- 专利标题： USE OF THE CD2 SIGNALING DOMAIN IN SECOND-GENERATION CHIMERIC ANTIGEN RECEPTORS
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申请号： US18170695申请日： 2023-02-17
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公开(公告)号： US20230242612A1公开(公告)日： 2023-08-03
- 发明人: Carl H. June , John Scholler , Avery D. Posey, Jr.
- 申请人： The Trustees of the University of Pennsylvania
- 申请人地址： US PA Philadelphia
- 专利权人： The Trustees of the University of Pennsylvania
- 当前专利权人： The Trustees of the University of Pennsylvania
- 当前专利权人地址： US PA Philadelphia
- 分案原申请号： US16460221 2019.07.02
- 主分类号： C07K14/725
- IPC分类号： C07K14/725 ; C07K16/28 ; C07K16/30 ; C07K14/705 ; C12N15/85
摘要：
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.
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