- 专利标题： DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE
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申请号： US18015561申请日： 2021-07-15
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公开(公告)号： US20230248834A1公开(公告)日： 2023-08-10
- 发明人: Bailin LEI , Huaqing LIU , Songzhe HAN , Zhiwei WANG
- 申请人： BEIGENE, LTD.
- 申请人地址： KY Camana Bay, Grand Cayman
- 专利权人： BEIGENE, LTD.
- 当前专利权人： BEIGENE, LTD.
- 当前专利权人地址： KY Camana Bay, Grand Cayman
- 优先权： WO TCN2020102501 2020.07.16 WO TCN2020113237 2020.09.03 WO TCN2021070896 2021.01.08 WO TCN2021101279 2021.06.21
- 国际申请： PCT/CN2021/106485 2021.07.15
- 进入国家日期： 2023-01-11
- 主分类号： A61K47/55
- IPC分类号： A61K47/55 ; A61K47/54
摘要：
Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.
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