A pneumatic tire is provided which has sufficiently reduced rolling resistance during high-speed running and which has sufficiently improved durability. In this pneumatic tire, which has a tread, at least one rubber layer forming the tread includes a rubber component containing styrene butadiene rubber and isoprene rubber, and is formed from a rubber composition with a loss tangent (30° C. tan δ) less than or equal to 0.14, measured under the conditions of 30° C., frequency 10 Hz, initial strain 5%, and dynamic strain rate 1%; defining Wt (mm) as the cross-section width, Dt (mm) as the outer diameter and virtual volume V (mm3) as the volume of the space occupied by the tire when said tire is installed on the standardized rim and has an internal pressure of 250 kPa, the pneumatic tire satisfies (Formula 1) and (Formula 2).


1600≤(Dt2×π/4)/Wt≤2827.4  (Formula 1)



[(V+1.5×107)/Wt]≤2.88×105  (Formula 2)