The present application discloses an aerogel composite heat preservation fire-proof plate and a manufacturing process thereof. The aerogel composite heat preservation fire-proof plate comprises an upper surface layer, a fire-proof layer, a heat insulation layer, a polyurethane layer, and a lower surface layer which are compositely arranged from top to bottom in sequence. The interior of the fire-proof layer is hollow and filled with aluminum hydroxide particles. Working holes are uniformly formed in the fire-proof layer. Sealing double-screw bolts are connected in the working holes. Aerogel mounting grooves are uniformly formed in the surface, close to the fire-proof layer, of the heat insulation layer. There are heat insulation air cavities at one side, far away from the fire-proof layer, of the mounting grooves. The air cavities are communicated with all the mounting grooves. Aerogel fillers are arranged in the mounting grooves.