A microneedle balloon catheter includes a balloon fluidically coupled to a first fluidic channel and microneedles fluidically coupled to a second fluidic channel. The microneedles are on an exterior surface of the balloon. The catheter also includes a guiding sheath. In a first position of the microneedle balloon catheter the balloon, the microneedles, and a portion of the first and second fluidic channels are housed within the guiding sheath. In a second position of the microneedle balloon catheter the balloon and the microneedles are arranged outside of the guiding sheath. The first and second fluidic channels are fluidically isolated from each other.