A preparation method of a polytetrafluoroethylene (PTFE)-based nano functional composite membrane and use is provided. The PTFE-based nano functional composite membrane can be applied to prevention and resistance of icing of various types of wind turbine generator blades in winter and salt spray corrosion resistance of wind turbine blades, in the meantime, can improve the aerodynamic performance of wind turbine blade airfoils and enhance the whole surface strength of the blade and protect the blade from undergoing aging erosion, and is a new-generation multi-functional brand-new composite membrane material which can be directly explored and applied to the industrial fields of preventing adhesion and corrosion of marine fouling organisms on steel pipe piles of offshore wind power and offshore platforms, avoiding snowing and icing of high-voltage transmission towers and cables, protecting snowing and icing of bridges (stay cables and suspension cables) and the like.