- 专利标题： METHOD FOR DIAGNOSING NONALCOHOLIC STEATOHEPATITIS
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申请号： US18024955申请日： 2021-06-15
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公开(公告)号： US20230333125A1公开(公告)日： 2023-10-19
- 发明人: Toshihiro SAKURAI , Shu-Ping HUI , Hitoshi CHIBA
- 申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY , EIKEN KAGAKU KABUSHIKI KAISHA
- 申请人地址： JP Sapporo-shi, Hokkaido
- 专利权人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY,EIKEN KAGAKU KABUSHIKI KAISHA
- 当前专利权人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY,EIKEN KAGAKU KABUSHIKI KAISHA
- 当前专利权人地址： JP Sapporo-shi, Hokkaido; JP Taito-ku, Tokyo
- 优先权： JP 20149798 2020.09.07
- 国际申请： PCT/JP2021/022648 2021.06.15
- 进入国家日期： 2023-03-06
- 主分类号： G01N33/92
- IPC分类号： G01N33/92
摘要：
A problem of the present invention is to provide a diagnostic biomarker of nonalcoholic steatohepatitis (NASH) useful for differentiation of simple steatosis (SS) from NASH and use thereof. Specifically, the present invention relates to a diagnostic biomarker of nonalcoholic steatohepatitis used to differentiate nonalcoholic steatohepatitis from simple steatosis comprising the oxidized apolipoprotein A-I (ApoA-I) modified by dioxidation of the 72nd tryptophan in the ApoA-I consisting of the amino acid sequence as shown in SEQ ID NO: 1.
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