Systems and methods for generating a virtual depiction of an orthodontic treatment of a patient are provided. In some embodiments, a system includes one or more processors, and a memory operably coupled to the one or more processors. The memory can include instructions that, when executed by the one or more processors, cause the system to perform operations including: receiving one or more 2D images of a patient’s face including a mouth region; extracting teeth contours of the patient’s teeth from within the mouth region of the received 2D images; generating, using a neural network, a 2D rendering depicting a post-treatment arrangement of the patient’s teeth; generating a realistic composite 2D image depicting the patient’s face with the 2D rendering depicting the post-treatment arrangement of the patient’s teeth; and sending the realistic composite 2D image to an output device for display on a user interface of the output device.