- 专利标题： CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR P95HER2 AND USES THEREOF
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申请号： US17999769申请日： 2021-05-28
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公开(公告)号： US20230348620A1公开(公告)日： 2023-11-02
- 发明人: Joaquin ARRIBAS LOPEZ , Irene RIUS RUIZ , Macarena ROMAN ALONSO , Alena GROS VIDAL , Carlos Alberto FAJARDO CALDERON , Christian KLEIN , Ekkehard MOESSNER
- 申请人： VALL D´HEBRON INSTITUTE OF ONCOLOGY (VHIO) , INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS
- 申请人地址： ES Barcelona
- 专利权人： VALL D´HEBRON INSTITUTE OF ONCOLOGY (VHIO),INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS
- 当前专利权人： VALL D´HEBRON INSTITUTE OF ONCOLOGY (VHIO),INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS
- 当前专利权人地址： ES Barcelona
- 优先权： EP 382457.8 2020.05.28
- 国际申请： PCT/EP2021/064383 2021.05.28
- 进入国家日期： 2022-11-23
- 主分类号： C07K14/725
- IPC分类号： C07K14/725 ; C07K16/32 ; C07K14/705 ; C07K14/73 ; C12N15/79 ; G01N33/563 ; A61P35/00
摘要：
The present invention relates to a chimeric antigen receptor (CAR) capable of targeting p95HER2-expressing cells. The invention also relates to a single-chain variable fragment (ScFv), to an antigen-binding domain and to an antibody or antibody fragment thereof capable of binding to the p95HER2 antigen. The invention also relates to a method of cancer diagnosis and to a pharmaceutical composition for use in a method of preventing or treating cancer comprising the CAR and/or the antigen-binding domain or the antibody of the invention.
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